사람 융모 성선 자극 호르몬에 의한 복강 대식세포로부터 산화질소의 발생

Nitric Oxide Generation from Peritoneal Macrophages by Human Chorionic Gonadotropin

Human chorionic gonadotropin (hCG) is a placental hormone and is involved in maintenance of the corpus luteum during pregnancy. In the present study, effect of hCG on nitiric oxide (NO) generation from peritoneal macrophage was examined. hCG ahd no effect on NO generation by itself, whereas recombinant interferon-gamma (rIFN-gamma) alone had modest activity. When hCG was used in combination with rIFN-gamma, there was a marked cooperative induction of NO generation in a dose-dependent manner. The optimal effect of hCG on NO generation was shown at 6 hr after treatment with rIFN-gamma. Furthermore, northern blot analysis of showed that hCG increased the expression of inducible NO synthase(iNOS) gene. These results suggest that hCG induces NO generation from macrophages by increasing the expression of iNOS gene.