학술저널
곰팡이 분리주 No. 51005로부터 포스포리파제 C 저해물질 앙길로스포랄의 분리
Isolation of Anguillosporal, a Potent Inhibitor of Phospholipase C from Fungi Isolate No. 51005
- 대한약학회
- 약학회지
- 제41권 제4호 (1997년)
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1997.08433 - 438 (6 pages)
- 20
MT 51005 as a potent inhibitor of phospholipase C(PLC) was purified from the culture broth of a fungal strain No. 51005 isolated from soil. It was identified as a benzaldehyde derivative, anguillosporal. by the physico-chemical properties and spectroscopic data. Anguillosporal showed the inhibitory activity against purified PLC with an IC50 of 13mcg/ml. And it also inhibited the formation of inositol phosphates(IPt) in platelet-derived growth factor(PDGF)-stimulated NIH3T3gamma1 cells with an IC50 of 0.8mcg/ml.
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