학술저널
항류우머티즘 물질인 p-(아세틸아미노)페닐아세트산의 합성
Synthesis of p-(Acetylamino)phenylacetic acid As an Antirheumatic Agent
- 대한약학회
- 약학회지
- 제41권 제4호 (1997년)
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1997.08480 - 483 (4 pages)
- 7
The efficient synthesis of p-(acetylamino)phenylacetic acid(7), a antirheumatic agent, is reported. Methyl phenylacetate(3) was prepared from Friedel- Crafts reaction of benzene with methyl alpha-chloro-alpha-(methylthio)acetate(1) followed by reductive desulfurization with zinc dust in acetic acid. Compound(7) was obtained from 3 by a sequence of nitration, reduction, N-acylation, and hydrolysis.
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