고탄수화물 식이 투여 마우스에서 상엽 컬럼분획물의 alpha-glycosidase 활성에 미치는 영향

Effect of Mori Folium Column Fraction on Intestinal alpha-glycosidase Activity in Mice Administered with a High Carbohydrate-Containing Diet

The effect of prolonged treatment with Mori Folium column fraction(MFCF) on intestinal alpha-glycosidase activity has been studied in mice made hyperglycemic and hyperinsulinemic by feeding a high carbohydrate-containing diet. Mice were treated for 10 week with or without MFCF, added to the high carbohydrate-containing diet at 50mg/100g food. While MFCF had no effect on body weight, it prevented the rise in glycemia and insulinemia. Maltase, sucrase and lactase activities were measured in intestinal homogenates of proximal, middle and distal segments of jejunoileum. Following 10 week of MFCF administration, MFCF significantly induced all three enzyme activities especially at middle and distal segments. The mechanisms responsible for these changes and their potential biochemical implications remain to be detemiined.