학술저널
입체선택적인 분자내 [2+2] 환화반응을 이용한 광학활성 Bicyclo[4.2.0]octanone의 합성
Synthesis of The Optically Active Bicyclo[4.2.0]octanone by Stereoselective Intramolecular[2+2]Cycloaddition
- 대한약학회
- 약학회지
- 제41권 제6호 (1997년)
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1997.12714 - 717 (4 pages)
- 19
Stereoselective synthesis of the optically active bicyclo [4.2.0] octanone 5 was accomplished using intramolecular olefin-keteniminium salt[2+2]cycloaddition of the amide 4 as a key step. This important chiral synthon was prepared starting from readily available L-glutamic acid via an efficient 8-step sequence.
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