톨루엔 흡입 흰쥐의 선조체에서 미세투석법을 이용한 세포외성 흥분성 아미노산 신경전달물질의 측정

Measurements of Extracellular Excitatory Amino Acid Neurotransmitter Levels in Corpus Striatum of Toluene Inhaled Rat by Microdialysis

Male Sprague-Dawley rats were exposed to the toluene at 3,000+/-200ppm via inhalation for two hours (single inhalation group), three weeks by two hours per day, six days per week (repeated inhalation group). We examined the level of excitatory amino acids of the extracellular neurotransmitter within the corpus striatum of rats by using in vivo microdialysis. Aspartate (Asp) and glutamate (Glu) of excitatory amino acid neurotransmitters were generally decreased in the inhalation groups compared with the control group, and more significantly decreased in the repeated inhalation group than in the single inhalation group except that Asp was increased from 60 min after the beginning of the inhalation to 30 min after the termination.