학술저널
참소리쟁이의 세포독성 성분
Cytotoxic Constituents of Rumex japonicus
- 대한약학회
- 약학회지
- 제42권 제3호 (1998년)
-
1998.06233 - 237 (5 pages)
- 16
Activity-guided fractionation and repeated column chromatography afforded two cytotoxic compounds R-3 and R-4 from the root of Rumex japonicus HOUTT. Compounds were identified as musizin and emodin, respectively, by the physicochemical and spectral data. Besides R-3 and R-4, two compounds R-1 and R-2, chrysophanol and physcion, respectively, were also isolated. The compound R-3 and R-4 exhibited cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15 with ED50 values ranging from 2.68 to 10.06mcg/ml.
(0)
(0)