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Determination of Chlorpromazine Using Plasticizers as Extraction Solvent

A method for the determination of basic drugs based on their reaction with picric acid to form an ion-association complex extractable into several plasticizers was developed. Basic drugs-picric acid complexes in acid medium could be extracted quantitatively into several plasticizers except phosphates. For example, the chlorpromazine-picric acid complex showed maximum absorbance at near 410nm and was applied to extraction spectrophotometric determination of chlorpromazine. The calibration curves are linear (r>0.998) within a range from 10-6 to 5 X 10-4M and the precision of the method was acceptable because RSD was less than 2.6% (n=7). The factors affecting the extraction system was discussed.