한약이 난소제거 흰쥐와 SAM P6 생쥐의 생리활성에 미치는 영향

Effects of Herbal medicine on Physiological Responses in Ovariectomized Rats and SAM P6 Mice

The effect of herbal medicine on osteoporosis was studied using ovariectomized rats as an animal model of Type I osteoporosis and SAM P6 mice as that of Type II. Each traditional boiling water extract of Achyranthis Radix, Psoraleae Radix, Rehmanniae Radix Preparat, Corni Fructus and Mycelia of Ganoderma, and systemic water fraction of Astragali Radix was given 5g(dried herbal weight)/kg/day p.o. for 30 days in each group of ovariectomized rats, SAM R1 and SAM P6. The extract of Cervi parvum Cornu was given for 14 days only. One ml of blood was taken by tail vein at day 0, 7, 14, 21 and 30 days after administration of the extract. Plasma levels of alkaline phosphatase, calcium, creatinine,inorganic phosphate, blood urea nitrogen, cortisol, total T3 and total T4 were measured. In ovariectomized rats, administration of Achyranthis Radix or Corni Fructus decreased in alkaline phosphatase and that of Achyranthis Radix or Psoraleae Radix decreased in calcium comparing to the control (p3 and total T4 in Type I(p3 concentration and that of Mycelia of Ganoderma also elevated cortisol level although there was no change in hormonal concentrations by Astragali Radix in SAM P6. However, the uptake of Mycelia of Ganoderma induced changes in cortisol and T4 concentrations in SAM R1(p0.05). Thus, there were significant differences in responses of herbal medicine in different types of osteoporosis.