학술저널
활성화한 RAW 264.7 세포주에서 8-epi-xanthatin의 Nitric Oxide 생성저해
Inhibition of Nitric Oxide Synthesis by 8-epi-xanthatin in Activated RAW 264.7 Cells
- 대한약학회
- 약학회지
- 제42권 제5호 (1998년)
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1998.10540 - 543 (4 pages)
- 8
The nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase is known to be responsible for the vasodilation and hypotension observed in septic shock. We have found that 8-epi-xanthatin from Xanthium strumarium L. inhibited the production of NO in LPS-activated RAW 264.7 cells (IC50 value was 1.5 mcM). This activity was resulted from the suppressing of inducible nitric oxide synthase enzyme expression.
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