근적외선 분광분석법을 이용한 타우린의 정량 분석

Quantitative Analysis of Taurine Using Near Infrared Spectrometry (NIRS)

Near Infrared transmittance Spectroscopy (NIRS) was used to evaluate and quantify the pharmaceutical active compounds. In the paper, taurine (2-Aminoethanesulfonic acid) was quantitatively analyzed in commercial pharmaceutical preparations. For calibration a central composite factorial design was used to determine concentrations of ingredients in reference samples. For the quantitative analysis of taurine, the most suitable data analysis method includes the calculation of second derivatives and a partial least squares regression (PLSR) model. By NIR spectrometry, combined with PLSR, the taurine concentration was successfully predicted with a relatrve standard error of prediction (SEP) lower than 1.04%.