학술저널
Bacillus sp. B-6가 생산하는 acyl CoA 합성 효소 억제 물질의 분리 및 구조 결정
Isolation and Structure Elucidation of Acyl CoA Synthetase Inhibitor from Bacilus sp. B-6
- 대한약학회
- 약학회지
- 제42권 제6호 (1998년)
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1998.12552 - 557 (6 pages)
- 5
Acyl CoA synthetase inhibitor, was purified from the culture broth of a Bacillus sp. B-6, which had been isolated from soil, by chloroform extract, silica gel column chromatography and preparative TLC. The purified acyl CoA synthetase inhibitor showed higher Antifungal activity against C. al-bicans (MIC: 8mcg/ml). Though the analysis of UV spectrum, melting point, IR spectrum, Mass-spectrum, 1H-NMR and 13C-NMR spectrum, the inhibitor could be identified as phenazine-l-carboxylic acid.
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