학술저널
청피에 함유된 복강 마크로파지의 탐식작용 억제 성분
A Suppressive Component on Phagocytosis of Murine Peritoneal Macrophage in Aurantii immaturi pericarpium
- 대한약학회
- 약학회지
- 제42권 제6호 (1998년)
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1998.12567 - 571 (5 pages)
- 21
The phagoeytic activity of murine peritoneal macrophage, was determined by lucigenin chemiluminescence and engulfment of fluorescein-conjugated E. coli particle. The activity-guided fractionation upon the methylenechloride fraction of Aurantii immaturi pericarpium led to the isolation of a flavonoid, isosinensetin, as a suppressive component of phagocytosis. Isosinensetin suppressed the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and enhanced the production of nitric oxide in murine peritoneal macrophage.
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