염화아연의 세포성 면역독성에 미치는 황기 추출물의 효과

Effects of Astragali Radix extract on the Cell Mediated Immunotoxicity of Zinc Chloride

Effects of Astragali Radix extract (AG) on the cell mediated- and nonspecific immunotoxic responses of zinc chloride (Zn) were studied using ICR mice. Mice were divided into 4 groups (10mice/group), and Zn was given to the mice 1hr after I.p. injection with 0.5g/kg of AG by I.p. injection daily for 10 days at a dose of 25mg/kg. Immune responses on the relative weight of thymus, delayed-type hypersensitivity to SRBC (DTH), phagocytic activity and circulating leukocytes were evaluated. Zn treatment decreased body weight gain, the relative weight of thymus, DTH and circulating leukocytes compared with those in controls. AG treatment increased DTH, phagocytic activity and circulating leukocytes compared with those in controls, Combination of AG and Zn increased DTH and circulating leukocytes compared with those in controls, but decreased body weight gam and the relative weight of thymus. Combination of AG and Zn increased DTH and circulating leukocytes than in Zn alone, but decreased body weight gain and the relative weight of thymus. These finding indicated that AG decreased immunotoxicity of Zn on the DTH and circulating leukocytes.