금은화 플라보노이드성분의 항염증작용

Anti-inflammatory Activity of the Flavonoid Components of Lonicera japonica

Because of the potent effects of lipid mediators such as Prostaglandins (PGs), leukotriens (LTs) and platelet activating factor (PAF) on a variety of cells and tissues, they are considered as major contributors to the process leading to inflammation and allergy. To pursue the mechanism of anti-inflammatory activity of Lonicera japonica, we tested inhibitory effects of 7 flavonoids from Lonicera japonica on arachidonic acid cascade related enzymes, such as inflammatory phospholipase A2, cyclooxygenase-1 and 2, 5-lipoxygenase, in bone marrow-derived mast cells (BMMC), and lyso PAF- acetyltransferase in rat spleen nicrosomes. Anti-inflammatory activities of Lonicera japonica are thought to be attributed at least in part to the inhibition of arachidonic acid cascade releated enzymes by flavonoids such as apigenin, luteolin and quercetin.