Lupane계 Triterpenoid류가 임파구 분열에 미치는 효과

Effcets of Lupane-Triterpenoids on Mitogen-induced Proliferation of Lymphocytes

The effects of five lupane-triterpenoids from leaves of two Acanthopanax spp., chiisanogenin, chisanoside and 22alpha-hydroxychiisanogenin, acakoreoside A and acantrifoside A on the mitogen-induced proliferation were investigated in vitro. T cell proliferation (TCP) to concanavalin A (Con A) and the B cell proliferation (BCP) to lipopolysaccharide (LPS) were increased by chiisanogenin. TCP to Con A was significantly increased by chiisanoside and acankoreoside A, but not affected by chiisanogenin, 22 alpha-hydroxychiisanogenin and acantrifoside A, BCP to LPS was significantly increased by acankoreoside A and acantrifoside A, and slightly increased by chiisanoside, chiisanogenin and 22 alpha-hydroxychiisanogenin.