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Determination of Basic Drugs with Ion-Selective Membrane Electrodes Using Ion-Exchanger

Many poly (vinyl chloride: PVC) membrane electrodes were investigated for the determination of basic drugs, chlorpromazine, amitriptyline, nortriptyline, etc. These electrodes are based on the use of the ion-association complexes of the basic drugs with eriochrome cyanine R, chromoxane cyanine, chrome azurol S and picric acid as ion-exchange sites in a plasticized PVC matrix. All ion-exchangers except picrate complex were not proper for use, because those complexes in plasticized membrane were excluded into aqueous working solution. These drug electodes show excellent Nernstian responses in the concentration range 10-2~10-6. Their selectivity with respect to each other, as well as their workable pH range have been investigated. The major advantages of the proposed methods are their simplicity and speed.