사염화탄소에 의해 유발된 간독성에 대한 상백피 추출물의 간보호효과

Protective Effects Of Extracts of Mori Cortex Radicis on Carbon Tetrachloride-induced Hepatotoxicity

In order to evaluate the protective effects of extracts of Mori cortex radicis on carbon tetrachloride induced hepatotoxicity, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, malondialdehyde values and glutathione S-transferase activity were measured in ICR mice. The activities of serum aminotransferase and the hepatic content of lipid peroxide after carbon tetrachloride-treatment were markedly increased than normal control but those levels were significantly decreased by the treatment of butanol fraction of Mori cortex radicis mathanol extract. Glutathione S-transferase activity was decreased by carbon tetrachloride than control, but that also inhibited by the treatment of butanol fraction of Mori cortex radicis methanol extract. These results demonstrate a possible hepatoprotective role of extracts of Mori cortex radicis against CCl4-induced hepatoxicity in vivo.