학술저널
Glycyl Norfloxacin 유도체의 합성과 항균작용
Synthesis and Antimicrobial Activity of Glycyl Norfloxacin Derivatives
- 대한약학회
- 약학회지
- 제43권 제4호 (1999년)
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1999.08442 - 446 (5 pages)
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The synthesis and antimicrobial activity of N-substituted glycyl derivatives of Norfloxacin were described. Norfloxacin was treated with chloroacetyl chloride to yield chloroacetyl norfloxacin(1). This compounds was treated with alkylamines to obtain quinolone carboxylic acids(2-6), which were reacted with pivaloyloxymethyl chloride to get pivaloyloxymethyl quinolone carboxylates(7-11). Free carboxylic quinolones(2-6) showed little stronger activities to their pivaloyloxymethyl esters(7-11). In quinolone analogues, longer alkyl chain compounds showed stronger activities than shorter one.
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