잔나비걸상버섯 수용성물질의 항인플루엔자바이러스 작용과 인터페론과의 병용효과

Anti-influenza Virus Activity of Water Soluble Substance from Elfvingia applanata Alone and in Combinations with Interferons

EA. the water soluble substance, was prepared from the carpophores of Elfvingia applanata(Pers.) Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A. EA showed a concentration-dependent reduction in the plaque formation of Flu A with 50% effective concentration (EC50) of 1.50mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.