학술저널
오미자에서 분리한 새로운 Chitin Synthase Ⅱ 저해제인 Gomisin N 과 Wuweizisu C
Gomisin N and Wuweizisu C, new Inhibitors for Chitin Systhase Ⅱ from Schizandra chinensis
- 대한약학회
- 약학회지
- 제43권 제4호 (1999년)
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1999.08509 - 515 (7 pages)
- 22
To search for new chitin biosynthesis inhibitors from natural sources, several higher plants were examined the inhibitory activity against chitin synthase Ⅱ by enzymatic assay. Among them, the extract of Schizandra chinensis strongly showed the inhibitory activity against chitin synthase Ⅱ. Gomisin N and wuweizisu C were isolated from Schizandra chinensis and showed IC50 value of 62.4mcg/ml and 19.2mcg/ml, respectively. Activities of these compounds were more stronger than that of polyoxin D. However, gomisin N and wuweizisu C showed weakly antifungal activities against various human pathogens.
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