홍화씨의 경골골절치유에 미치는 영향

Effects of Safflower-seed on the Fracture Healing in Rat Tibia

We investigated the effect of safflower-seed on fracture healing of fracture model in rat. Fracture healing was evaluated by examining the degree of wound healing macroscopically, radiography, bone histomorphometry and biochemical examination. After 1,3,5,7 days, the wound healing was accelerate in safflower-seed diet group. Radiography does not reveal the difference in fracture healing between two groups. After 2 weeks, safflower-seed had a significant, stimulatory effect on external callus formation(p<0.05). But after 4,6,8 weeks, no difference was observed between normal and safflower-seed diet group in callus size. Urinary hydroxyproline, osteocalcin and total alkaline phosphatase decreased significantly (p<0.05) in safflower-seed treated group at 2 week after fracture.