학술저널
새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성
Synthesis and Antitumor Activity of Novel Gericudranin E Derivatives
- 대한약학회
- 약학회지
- 제43권 제5호 (1999년)
-
1999.10559 - 565 (7 pages)
- 35
The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their anti-tumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.
(0)
(0)