호장근의 사염화탄소로 유도된 지질과산화 저해활성

Antilipoperoxidant Activity of the Root of Polygonum cuspidatum on Carbon Tetrachloride Induced Hepatotoxicity

The root of Polygonum cuspidatum (Polygonaceae) has been used as treatments of hyper-lipidemia, dermatitis, gonorrhea, favus athlete's feet, inflammation in traditional medicine. In order to examine anti-lipidperoxidation activity, hexane, EtOAc, BuOH and water fractions of its methanol extract were administered to carbon tetrachloride intoxicated rats. Ethylacetate fraction exhibited antilipidperoxidative effect on liver lipid homogenate and the radical scavenging effect on DPPH. Serum transaminase, A/P, triglyceride and total cholesterol contents signigicantly decreased by administrations of ethylacetate fraction.