개의 신장기능에 미치는 Ketanserin의 영향

Effect of Ketanserin on Renal Function in Dogs

This study was performed in order to investigate the effect of ketanserin, a spcific antagonist of 5-HT2 receptor, on renal function in dogs. Ketanserin (50.0 and 15.0mcg/kg), when given intravenously, produced antidiuretic action accompained with the decreased amounts of sodium and potassium excreted in urine (ENa, EK) and the increased reabsorption rates of sodium and potassium in renal tubules (RNa, RK). Ketanserin (15.0 and 50.0mcg/kg) injected into the carotid artery exhibited also antiduretic action and this antidiuretic action was not affected by renal denervation. Above results suggest that ketanserin elicits antidiuretic action through central function, this central antidiuretic action is not mediated by renal nerves.