학술저널
ATP-의존성 K+ Channel 차단제인 Gilbenclamide의 중추적 이뇨작용에 대한 신장 신경제거와 Cromakalim의 영향
Effects of Renal Denervaton and Cromakalim on Central Diuretic Action of Gilvenclamide, an ATP-dependent K+ Channel Blocker, in Dogs
- 대한약학회
- 약학회지
- 제43권 제5호 (1999년)
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1999.10674 - 681 (8 pages)
- 5
This study was performed to investigate the effect of renal denervation and cromakalim, a K+ channel opener, on central diuretic action of glibenclamide, an ATP-dependent K+ channel blocker, in dog. Diuretic action of glibenclamide administered into the vein was weakened markedly by renal denervation and pretreatment of cromakalim. Above results suggest that central diuretic action of glibenclamide is mediated by renal nerves and K+ channel localized in kidney.
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