학술저널
UVB조사에 의한 페플록사신의 광독성 유발 기전
Phototoxic Potential Mechanism of Pefloxacin Irradiated by UVB
- 대한약학회
- 약학회지
- 제43권 제6호 (1999년)
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1999.12703 - 708 (6 pages)
- 0
The effect of antioxidants on photochemical reaction of pefloxacin by UVB (290~320nm) was investigated and the possible mechanism of phototoxicity on the skin was also studied. The photodegradation of pefloxacin by UVB was suppressed by cysteine, reduced glutathione and ascorbic acid, but was promoted by alpha-tocopherol. Squalene, accounts for more than 10% of skin surface lipids, was peroxidized by pefloxacin through both radical and singlet oxygen mechanism.
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