학술저널
5,6-디플루오르-2-아미노인단.염산염의 합성
Synthesis of 5,6-difluoro-2-aminoindan.HCl
- 대한약학회
- 약학회지
- 제43권 제6호 (1999년)
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1999.12751 - 755 (5 pages)
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3,4-Difluoroamphetamine.HCl and 5,6-difluoro-2-aminoindan.HCl were synthesized as serotonergic agents. 3,4-Difluorobenzaldehyde was condensed with nitroethane and reduced with LiAlH4 to obtain 3,4-difluoroamphetamine. And 5,6-difluro-2-aminoindan.HCl was synthesized through reactions of condensation with malonic acid, 10% Pd-C reduction, cyclization with polyphosphroic acid, oximation and catalytic hydrogenation.
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