Flavin mononucleotide를 탈리기로한 백금(II) 착체의 합성과 그 항암활성

Synthesis of Pt(II) Complexes containing Flavin mononucleotide as Leaving Ligand and their Anticancer Activity

A series of vitamin-containing PT(II) complexes of the type [Pt (FMN) (L)] (FMN=flavin mono-nucleotide, L=ethylenediamine, 1,3-propanediamine, 1,4-bu- tanediamine) was synthesized and characterized by IR, electronic absorption, elemental analysis and FAB-Mass. The coordination sites of FMN to PT(II) ions were determined to be N(5) and 0(6) with resultant chelate ring formation. Theses compounds have much better water solubility (30-35mg/ml) than cisplatin (1mg/ml). The anticancer activity of this vitamin-containing PT(II) series was investigated by MTT assay against mouse and human leukemia cell lines in vitro. Among these compounds, FMN (1,4-butanediamine) PT(II) having seven-membered ring structure as amine ligand showed moderate anticancer activity.