학술저널
Cyclooxygenase-1과 Cyclooxygenase-2에 대한 4,5-Diarylpyrroles의 Docking Mode
Docking Mode of 4,5-Diarylpyrroles into Cyclooxygenase-1 and Cyclooxygenase-2
- 대한약학회
- 약학회지
- 제43권 제6호 (1999년)
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1999.12776 - 781 (6 pages)
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Dockings of 4,5-diarylpyrrroles into cyclooxygenase-1 and cyclooxygenase-2 were carried out by GOLD program. The sulfonyl groups bonded to 5-phenyl ring of 4,5-diarylpyrrroles are directed to Arg513 of COX-2 and Tyr385 of COX-1. COX-2 docking modes of pyrroles are different from COX-1. Tyr385 and Argl2O of COX-1 and COX-2 have been recognized as important residues. Val523 of COX-2 may be also important. A new COX-2 selective inhibitors could be designed from the docking study.
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