크로몬 유도체의 물성 및 활성검색

Properties and Activity Screening of Chromone Derivatives

We have synthesized 4-isonitroso-4H-1-benzopyran and 4-amino-2,3-dihydro-4H-1-benzopyran of chromone derivatives by using condensation method. Physico-chemical properties of these compounds were measured and analyzed by UV and HPLC method. The correaltion coefficient of their methanol solutions by UV were 0.9992 and 0.9994, respectively. And oxime compound was resolved within 4 min and had a detection limit of 3ng at S/N=3 by HPLC under the same conditions. Anti-diabetic effect of chromone derivatives were investigated in the streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in male Sprague-Dawley rats by injections of STZ (45mg/kg, I.v.). The investigation of the hair growth effect of isonitrosobenzopyran and 4-aminobenzopyran on the hair of black mouse (C57BL/6) was also carried out. The administration of their ethanol solution to the black mouse (C57BL/6) through skin them promoted the growth of hair.