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새로운 세파로스포린 항생제 DA-074의 in vitro 항균력과 감염치료효과

In vitro Activities and in vivo Efficacies of DA-074 a New Cephalosporin

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The in vitro activities of DA-074, a new cephalosporin against 34 various standard strains and its in vivo efficacies against 6 important strains were obtained. DA-074 showed two fold enhanced in vitro antibacterial activity against some Pseudomonas aeruginosa compared to Ceftazidime and more than 2 fold in vivo efficacy against Staphylococcus aureus Smith, Klebsiella pneumoniae 1 and Eschetichia coli KC-14, compared to Cefpirome. DA-074 might be a good candidate for further evaluations.

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