학술저널
새로운 1,2-다이아제피노 [3,4-b]퀴녹살린류와 피리다지노 [3,4-b]퀴녹살린류의 합성
Synthesis of Novel 1,2-Diazepino[3,4-b]quinoxalines and Pyridazino[3,4-b]quinoxalines
- 대한약학회
- 약학회지
- 제44권 제4호 (2000년)
-
2000.08325 - 333 (9 pages)
- 0
The 1,3-dipolar cycloaddition reaction of the quinoxaline 4-oxides 2 with 2-chloroacrylonitrile gave the 2,3-dihydro-1H-1,2-diazepino[3,4-b]quinoxalines 3, which were converted into the 2,3,4,6-tetrahydro-1H-1,2-diazepino[3,4-b]quinoxalines 5-7. The reaction of compounds 3 with selenium dioxide in acetic acid/water resulted in ring transformation to give the 1,4-dihydro-4-oxopyridazino[3,4-b]quinoxalines 8.
(0)
(0)