한약재(자하거, 백출, 차전자) 추출물의 간경화 억제효능에 관한 연구

Antifibrotic Effects of Oriental Herbs Extraction on liver Cirrhosis

Hepatic cirrhosis is an important feature of chronic liver disease, Liver cirrhosis is characterized by hyperaccumulation of fibrous tissue components and is commonly observed in latter or terminal states of chronic hepatic discase. The antifibrotic effects on liver cirrhosis by oriental herbs extraction meterial were examined in bile duct ligated rats. Oriental herbs extraction (0.99 mg/kg rat weight/day) was administrated to cirrohotic rats for 4 weeeks. Liver collagen content of bile duct ligated rats was significantly increased. And histology showed collagen fiber deposition was increased as well as the normal architecture was lost with large zone of nccrosis being observed. Herbs extraction administrated rats showed significantly decreased liver collagen content, accumulation of collagen fiber in histological analysis, and biochemical markers of hepatic diseases. Those results demonstrate the usefulness of herbs extraction materials as an antifibrotic agent for liver cirrhosis.