학술저널
1,4-위치에 측쇄를 가진 신규 뉴크레오사이드의 합성 및 항바이러스 약효검색
Synthesis of Novel 1,4-Disubstituted Nucleosides as Potential antitumor Agents
- 대한약학회
- 약학회지
- 제51권 제2호 (2007년)
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2007.04103 - 107 (5 pages)
- 14
In these study, novel 1,4-disubstituted carbocyclic nucleoside analogues were synthesized as potential antiviral agents. The coupling reaction of the alcohol 8α with natural bases using Mitsunobu reaction afforded the target nucleosides 13, 14. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2 and HCMV. Cytosine derivative 13 exhibited moderate antiviral activity against HIV-1 (EC50=16.4μM).
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