호장으로부터 분리한 안트라퀴논 및 스틸벤 화합물의 지질과산화 저해활성

Antilipoperoxidant Activity of Anthraquinone and Stilbene from Polygunum cuspidatum

Polygunum cuspidatum has veen used as treatments of dermatitis, gonorrhea, inflammation, and hyperlipidaemia in traditional medicine. We examined liver protective effect on CCl4 inducing hepatotoxicity, and anti-oxidative activity by TBA method. Phytochemical examination of Polygunum cuspidatum led to the isolation and characterization of emodin 8-O-β-D-glucopyranoside (compound 1), and trans-resveratrol 3-O-β-D-glucopyranoside (compound 2). Compounds 1 and 2 enhanced the inhibition of anti-lipid peroxidative effects in liver homogenate. In chemical parameters obtained from serum analysis, compounds 1 and 2 also revealed significant decrease in hepatotoxicity. These results suggested that the analysis, compounds 1 and 2 also revealed significant decrease in hepatotoxicity. These results suggested that the anthraquinone and stilbene which were isolated from Polygunum cuspidatum might be used as therapeutic agent of hepatitis.