학술저널
목향(木香)으로부터 분리된 Sesquiterpene 화합물의 암세포 생육저해에 대한 활성
Sesquiterpene Lactones from Saussurea lappa and Their Cell Proliferation Effects on Human Breast Cell Lines
- 대한약학회
- 약학회지
- 제51권 제2호 (2007년)
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2007.04145 - 149 (5 pages)
- 38
Saussurea Radix, the dried roots of Saussurea lappa Clark (Compositae), has been used in oriental traditional medicine for aromatic stomachic. Present study was carried out for the anticancer effect of Saussurea Radix. Bioassay-directed fractionation of Saussurea Radix led to the isolation of two sesquiterpenes, dehydrocostuslactone (1) and costunolide (2). The structures of 1 and 2 were elucidated by spectral methods (MS, IR, 1H and 13C NMR). These compounds showed a potent cell proliferation activity against human breast cancer cell MCF-7 and MDA-MB-453.
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