사염화탄소에 의해 유도된 흰쥐의 간장해에 미치는 지잠의 보호효과

Hepatoprotective Effects of the Water Extract of Protaetia brevitarsis Larva Against Carbon Tetrachloride-Induced Liver Injury in Rats

Hepatoprotective effects of the water extract of Protaetia brevitarsis larva (PB) was investigated in carbon tetrachloride (CCl4) treated male Sprague-Dawley rats. PB administration protected rats against ALT, AST and LDH elevations induced by CCl4, as well as the severity of liver damage. PB recovered the decrease in serum level of high-density lipoprotein-cholesterol and the increase in serum level of low-density lipoprotein-cholesterol induced by CCl4. In histopathological observation, massive fatty change and necrosis in the centrilobular area, degenerative change including pyknosis of nucleus and swelling of parenchymal cell induced by CCl4 were clearly protected by PB. These histopathological findings paralleled with the serum biochemical results. The present results demonstrated that the water extract of PB may have the hepatoprotective effect against CCl4-induced liver damage in vivo.