학술저널
마우스에서 L-Theanine의 기억력 회복능 및 Acetylcholinesterase 활성 억제
Improvement of Memory Impairment by L-Theanine Through Inhibition of Acetylcholinesterase Activity in Mice
- 대한약학회
- 약학회지
- 제51권 제6호 (2007년)
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2007.12409 - 414 (6 pages)
- 19
Acetylcholinesterase (AChE) plays a role in the progression of Alzheimer’s disease (AD). In this study, we examined the improving effect of L-theanine, a major amino acid in Japanese green tea (Camellia sinensis) on the scopolamine (1 mg/kg/mouse)-induced memory dysfunction in mice. Treatment with L-theanine (2, 4 mg/kg/mouse p.o.) in the drinking water for 7 days reversed the scopolamine-induced latency time and distance in the water maze test, latency time in the passive avoidance test, and inhibited AChE activity. This study suggests that L-theanine may be a useful agent for prevention of progression of AD.
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