Androstane과 Cholestane 유도체의 진통, 소염 및 항고지혈 효과

Antinociceptive, Antiinflammtory and Antihypercholesterolemic Effects of Androstane and Cholestane Derivatives

Seven epoxy- and hydroxyandrostane derivatives (DH-1~DH-7) and nine epoxy- and hydroxycholestane derivatives (CH-1~CH-9) with unsaturation in ring A and ring B were synthesized from DHEA and cholesterol, respectively. The antinociceptive effects of all synthesized compounds were measured by hot plate method. Most of androstane derivatives except 1α,2α-epoxy-4,6-androstadiene-3,17-dione (DH-3), and CH-6, CH-7 and CH-9 exhibited antinociceptive effect. 1,4-Androstadiene-3β,17β-diol (DH-5, 100 mg/kg, 35.8±7.39), 6α,7α-epoxy-1,4-androstadiene-3,17-dione (DH-4, 100 mg/kg, 32.6±5.50) and 5α,6α-epoxy-17-oxo-androstan-3β-ol (DH-1, 100 mg/kg, 32.5±2.98) were more effective than morphine (10 mg/kg, 30.6±0.5). The analgesic effects of androstane derivatives on acetic acid writhing in mice were lower than aspirin. The androstane derivatives were less effective than ibuprofen at inhibiting effects on the carrageenin induced paw oedema. 4,6-Cholestadien-3β-ol (CH-5), 1α,2α-epoxy-4,6-cholestadien-3β-ol (CH-7) and 7α-hydroxy- 4-cholesten-3-one (CH-9) showed the decrease of serum triglyceride and total cholesterol levels in poloxamer P-407 injected rat.