학술저널
8-아미노우고닌 유도체의 Prostaglandin E2 생성에 대한 저해작용
Inhibitory Activity of 8-Aminowogonin Analogues Against Prostaglandin E2 Production
- 대한약학회
- 약학회지
- 제52권 제1호 (2008년)
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2008.0285 - 91 (7 pages)
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8-Acyl and 8-sulfonylamidowogonin analogues were synthesized as potential anti-inflammatory agents. Nitration of 5,7-dihydroxyflavone (chrysin) followed by methylation of phenol groups and reduction of nitro group yielded 8-aminowogonin analogues. Acylation and sufonylation of 8-aminowogonin followed by demethylation reactions gave the title compunds. The synthesized wogonin analogues showed much reduced inhibitory activity on prostaglandin E2 (PGE2) production.
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