학술저널
황촉규 추출물의 Nitric Oxide 생성 저해활성
Inhibition of Nitric Oxide Production by the Extracts of Hibiscus manihot
- 대한약학회
- 약학회지
- 제52권 제4호 (2008년)
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2008.08259 - 263 (5 pages)
- 56
Anti-inflammatory activity of the extracts of Hibiscus manihot was investigated through the evaluation of its inhibitory effect on the production of inflammatory biomarkers (i-NOS, COX-2) in RAW264.7 murine macrophage cells. Among the sequential solvent fractions (hexane, dichloromethane, ethyl acetate, n-butanol and water), the fractions of dichloromethane (1 μg/ml) and ethyl acetate (5 μg/ml) showed potential inhibitory activities on i-NOS and COX-2 activity in RAW264.7 cells. These results suggest that Hibiscus manihot might have an anti-inflammatory activity through the suppression of inflammatory markers.
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