학술저널
녹차추출물/L-Theanine 혼합물의 Secretase 활성 억제 및 세포사 억제를 통한 기억력 회복능
Improvement of Memory Impairment of Green Tea Extract/L-Theanine Through Inhibition of Secretase Activity and Cell Death In Vivo
- 대한약학회
- 약학회지
- 제52권 제5호 (2008년)
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2008.10384 - 393 (10 pages)
- 24
We examined the effect of green tea extract (GTE) and L-theanine combination on the Aβ1-42-induced memory dysfunction. GTE and combination were administrated into mice for 3 weeks followed by injection of Aβ1-42 to induce memory impairment. GTE and L-theanine administration significantly improved cognitive ability and reduced Aβ1-42 level accompanied with the inhibition of neuronal cell death and activities of secretase. These results suggest that GTE and L-theanine combination may be a useful for preventing for the development or progression of Alzheimer’s disease.
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