Pedunculagin의 NK cell에 대한 활성화와 흑색종의 전이 억제 효과

Enhancement of NK Cytotoxicity and Antitumor Effect on Melanoma by pedunculagin

Pedunculagin is an ellagitannin purified from Alnus hirsuta var. microphylla, Betulaceae. The effects of pedunculagin on immune system have been characterized to induce enhancement of NK (natural killer) cell cytotoxicities against tumor cells. Here, we report the evaluation of the effects of pedunculagin on the growth of murine B16-FlO melanoma in vivo. After the intradermal inoculation of B16-FlO melanoma, B16-FlO tumors grew progressively in immunocompetent syngenic C57BL/6 mice. The mice treated with pedunculagin(10mg/kg, every 48hrs) resulted in a significant improvement in survival. Inhibitory effects of pedunculagin on lung metastasis in C57BL/6 mice were also detected. Summarizing treatment with pedunculagin has a significant antitumor effect upon B16-FlO murine melanoma.