Pedunculagin의 Macrophage에 대한 항암활성 및 Nitric Oxide 생성

Augmentation of Macrophage Cytotoxicity and NO Production by Pedunculagin

Pedunculagin is an ellagitannin purified from Alnus hirsuta var. microphylla, Betulaceae. The effects of pedunculagin on the immune system have been characterized to induce enhancement of NK (natural killer) cell cytotoxicities against tumor cells. The present study investigated whether pedunculagin can enhance macrophage cytotoxicity against P815 tumor cells. Macrophage cultured with pedunculagin enhanced cytotoxicity in a dose dependent manner. In addition, the same treatments increased NO production, which plays important roles in the immune system. Taken together, these results demonstrate that pedunculagin significantly enhances cytolytic activities of macrophage.