토끼에 있어서 SYC-fentanyl 패취제의 경피투여 동태비교

Comparative Pharmacokinetics for Dermal Application of a New SYC-fentanyl Patch in Rabbits

We examined a dermal pharmacokinetics for a new SYC-fentanyl patch in rabbits. Determination of fentanyl in the plasma was performed using a gas chromatography with nitrogen-phosphorus detection system and a capillary column. One patch per animal (fentanyl 2.5mg) was applied to clipped back skin for 72 hours. The plasma fentanyl concentration profile of SYC-patch was similar to that of a conventional patch (Durogesico(R), Janssen Co.). No significant difference was observed in the pharmacokinetic parameters, the area under the concentration-time curve (AUCO-72hrs) and the total area under the first moment-time curve (AUMCO-72hrs), between the two patch types. The AUCO-72hrs and AUMC0-72hrs of durogesic(R) were 183.3+/-46.28ng*hr/ml and 6,450+/-1,939ng*hr2/ml and those of SYC-fentany patch were 217.2+/-50.51ng*hr/ml and 8,022+/-2,245ng*hr2/ml, respectively (n=3). This result indicates that the new SYC patch has a similar bioavailability compared to durogesic(R) patch. Therefore, the SYC-patch may be considered as a bioequivalent fentanyl patch.