사람 카다베르 피부를 통한 케토롤락 트로메타민의 경피 흡수에 L-menthol이 미치는 영향

Effect of L-Menthol on the Percutaneous Absorption of Ketorolac Tromethamine Across Human Cadaver Skin

Transdermal delivery of ketorolac tromethamine, a potent non-narcotic analgesic, through human cadaver skin was investigated in vitro. A mixture of ethanol/water (40/60) containing 0, 1, 3, 5, and 8 (w/v)% L-menthol were used as a vehicle and penetration enhancer, respectively. The permeation of ketorolac through human cadaver skin from saturated drug solution was evaluated at 37oC with modified Franz diffusion cell. The in vitro skin flux and lag time were 1.23+/-0.11mcg/cm2.hr and 5.56+/-0.34hr, respectively. The cumulative amount of penetrated ketorolac containing L-menthol in ethanol/water (40/60) binary system was increased by the following order; 3%, 5%, 8%, 1%, 0%, and the lag time was decresed by the following order; 3%, 5%, 8%, 0%, 1%. The results suggested that a potential use of 3% L-menthol is an effective penetration enhancer of ketorolac tromethamine through the human cadaver skin.