사람 말초혈액 단핵세포에서 흰털오가피 열매 추출물에 의한 Th1/Th2 Cytokine 분비조절
Modulation of Thl/Th2 Cytokine Secretion in Human Peripheral Blood Mononuclear Cells by Water Extract of Acanthopanax divaricatus var. albeofructus Fruits
- 대한약학회
- 약학회지
- 제52권 제1호 (2008년)
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2008.0227 - 32 (6 pages)
- 42
Water extracts of Acanthopanax divaricatus var. albeofructus (ADA) fruits were used to treat hPBMC to determine the mechanisms for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL- 2, L-12, IFN-γ and TNF-α) and Th-2 type (IL-6, IL-8 and IL-10) were measured using ELISA. A significant increase of Th- 1 type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that ADA fruit extract may influence the anticancer immune responses towards a predominance of Th-1 cytokines in the immune system.
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