학술저널
2-알킬-2,3-다이하이드로-1H-2-아자사이클로펜타[b]안트라센-5,10-디온계 유도체 합성 및 세포독성
Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene-5,10-diones
- 대한약학회
- 약학회지
- 제53권 제1호 (2009년)
-
2009.0241 - 44 (4 pages)
- 11
A series of 2-alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene- 5,10-diones (3a~h) were synthesized and evaluated in vitro cytotoxicity against colon cancer cell lines (HCT116 and SW620) and nuroblastoma cell lines (SK-N-SH and SK-N-MC). Among them, compound 3f showed significant cytotoxic activity (IC50 against SK-N-SH; 14.8 μM, IC50 against SK-N-MC; 11.3 μM).
(0)
(0)