학술저널
Chiral Drugs의 광학분할을 위한 HPLC Column의 응용
The Application of Chiral HPLC Columns for Enantiomer Separation of Chiral Drugs
- 대한약학회
- 약학회지
- 제53권 제2호 (2009년)
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2009.0460 - 68 (9 pages)
- 36
In terms of chiral issue, two enantiomers of chiral drugs often differ significantly in their pharmacological, toxicological and pharmacokinetic profile. Chiral switches of racemic drugs have been redeveloped as single enantiomers. Several chiral resolution techniques in chirotechnology are introduced and the most used chiral HPLC chromatographic method among several chiral analysis techniques is described with its several advantages. Several types of chiral HPLC columns derived from their chiral selectors are discussed with their property and applications for enantiomer separation.
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